On 1 July 1862, Princess Alice married Prince Louis of Hesse and by Rhine (12 September 1837 - 13 March 1892), the son of Prince Charles of Hesse and by Rhine and the nephew of Louis III, Grand Duke of Hesse and by Rhine (9 June 1806 - 13 June 1877), at Osborne House on the Isle of Wight. On the day of the wedding, Queen Victoria issued Letters Patent granting her new son-in-law the style Royal Highness. This style was in effect in Great Britain, not Hesse. Alice and Louis took up residence at Darmstadt, Hesse. The couple had seven children. It was later learned that Alice carried and passed on the haemophilia gene she inherited from Queen Victoria to several of her own children.